Looking at the underlying holdings of the ETFs in our coverage universe at ETF Channel, we have compared the trading price of each holding against the average analyst 12-month forward target price, and computed the weighted average implied analyst target price for the ETF itself. For the First Trust NYSE Arca Biotechnology Index Fund ETF (FBT), we found that the implied analyst target price for the ETF based upon its underlying holdings is $184.23 per unit.

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With FBT trading at a recent price near $152.17 per unit, that means that analysts see 21.07% upside for this ETF looking through to the average analyst targets of the underlying holdings. Three of FBT's underlying holdings with notable upside to their analyst target prices are EXACT Sciences Corp. (EXAS), Acadia Pharmaceuticals Inc (ACAD), and Agios Pharmaceuticals Inc (AGIO). Although EXAS has traded at a recent price of $42.23/share, the average analyst target is 46.82% higher at $62.00/share. Similarly, ACAD has 34.45% upside from the recent share price of $15.04 if the average analyst target price of $20.22/share is reached, and analysts on average are expecting AGIO to reach a target price of $38.25/share, which is 33.41% above the recent price of $28.67. Below is a twelve month price history chart comparing the stock performance of EXAS, ACAD, and AGIO:

Combined, EXAS, ACAD, and AGIO represent 10.00% of the First Trust NYSE Arca Biotechnology Index Fund ETF. Below is a summary table of the current analyst target prices discussed above:

Are analysts justified in these targets, or overly optimistic about where these stocks will be trading 12 months from now? Do the analysts have a valid justification for their targets, or are they behind the curve on recent company and industry developments? A high price target relative to a stock's trading price can reflect optimism about the future, but can also be a precursor to target price downgrades if the targets were a relic of the past. These are questions that require further investor research.